A method and an Evolved Node Base-station (eNB) for avoiding an occurrence of a ping-pong handover between adjacent cells are provided. The eNB comprises: a statistics module, a storage module, a judging module and a parameter adjusting module. The method includes: during a statistics period, eNBs serving two adjacent cells involved in a ping-pong handover, making a statistics on times of the serving cell of the eNB being used as a source cell and a target cell in a second handover in a process of each ping-pong handover occurring between the two adjacent cells respectively; upon the end of the statistics period, if the eNB determines that the times of the serving cell of the eNB being used as the source cell in the second handover is greater than the times of as the target cell, the eNB increasing a value of a handover control parameter of this serving cell.