发明申请
US20120077979A1 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors
失效
6,6-双环取代杂双环蛋白激酶抑制剂
- 专利标题： 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors
- 专利标题（中）： 6,6-双环取代杂双环蛋白激酶抑制剂
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申请号： US13308694申请日： 2011-12-01
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公开(公告)号： US20120077979A1公开(公告)日： 2012-03-29
- 发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
- 申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
- 专利权人： OSI Pharmaceuticals, LLC
- 当前专利权人： OSI Pharmaceuticals, LLC
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07F5/02
摘要：
Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.