A device for deploying fasteners including a handle and at least one actuator. The handle is connected to an elongated hollow housing having distal and proximal ends. The device has a first cartridge containing at least one fastener releasably connectable to the handle. The device also includes an elongated pusher movable through the hollow housing from the proximal to the distal end to deploy the fasteners. The device further includes a deforming member for deforming the pusher at a proximal end thereof while advancing the pusher to the distal end of the housing.