发明申请
US20120083627A1 Method of Synthesis of Arylsulfur Trifluorides and Use as in situ Deoxofluorination Reagent
审中-公开
芳基三氟化硫的合成方法，用作原位脱氟氟化试剂
- 专利标题： Method of Synthesis of Arylsulfur Trifluorides and Use as in situ Deoxofluorination Reagent
- 专利标题（中）： 芳基三氟化硫的合成方法，用作原位脱氟氟化试剂
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申请号： US13249385申请日： 2011-09-30
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公开(公告)号： US20120083627A1公开(公告)日： 2012-04-05
- 发明人: William R. Dolbier, JR. , Wei Xu
- 申请人： William R. Dolbier, JR. , Wei Xu
- 申请人地址： US FL Gainesville US SC West Columbia
- 专利权人： FLUOROTECH, LLC,OAKWOOD PRODUCTS, INC.
- 当前专利权人： FLUOROTECH, LLC,OAKWOOD PRODUCTS, INC.
- 当前专利权人地址： US FL Gainesville US SC West Columbia
- 主分类号： C07C381/00
- IPC分类号： C07C381/00
摘要：
The invention is a method of synthesizing Arylsulfur Trifluorides, such as Fluolead, by reacting BR2 and KF (or suitable alkali metal fluoride) in acetonitrile (or other suitable solvent). The invention also comprises using the Fluolead (or its substitutes), thus prepared, in situ as deoxofluorination reagents with a suitable aldehyde, ketone, or alcohol such as one selected from the group consisting of benzaldehyde Benzaldehyde, p-Bromobenzaldehyde, p-Tolualdehyde, Acetophenone, 2-Butanone, or Isobutyraldehyde, wherein the mixture is heated to reflux until completion. The respective products are then isolated after extraction by hexane and destruction of the sulfinyl fluoride co-product.
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