发明申请
- 专利标题: INHIBITORS OF FATTY ACID AMIDE HYDROLASE
- 专利标题(中): 脂肪酸酰胺水解酶抑制剂
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申请号: US13263324申请日: 2010-04-07
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公开(公告)号: US20120088738A1公开(公告)日: 2012-04-12
- 发明人: Alfredo C. Castro , Catherine A. Evans , Louis Grenier , Michael L. Grogan
- 申请人: Alfredo C. Castro , Catherine A. Evans , Louis Grenier , Michael L. Grogan
- 申请人地址: US MA Cambridge
- 专利权人: INFINITY PHARMACEUTICALS ,INC
- 当前专利权人: INFINITY PHARMACEUTICALS ,INC
- 当前专利权人地址: US MA Cambridge
- 国际申请: PCT/US10/30276 WO 20100407
- 主分类号: A61K31/69
- IPC分类号: A61K31/69 ; A61P29/00 ; A61P37/00 ; A61P19/02 ; A61P25/22 ; A61P25/00 ; A61P9/00 ; A61P25/06 ; C07F5/02 ; A61P25/24
摘要:
Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2, R3, R4, m and n are defined herein. Also provided are pharmaceutically acceptable compositions that include a compound of formula I and a pharmaceutically acceptable excipient. Also provided are methods for treating an FAAH-mediated disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound or composition of the present invention.
公开/授权文献
- US08541581B2 Inhibitors of fatty acid amide hydrolase 公开/授权日:2013-09-24