发明申请
US20120088791A1 AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME
审中-公开
氨基磷酸酯羧甲基纤维素M1同种异体激动剂，其类似物及其衍生物及其制备方法和使用方法
- 专利标题： AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME
- 专利标题（中）： 氨基磷酸酯羧甲基纤维素M1同种异体激动剂，其类似物及其衍生物及其制备方法和使用方法
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申请号： US13202272申请日： 2010-02-19
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公开(公告)号： US20120088791A1公开(公告)日： 2012-04-12
- 发明人: Craig W. Lindsley , Jeffrey P. Corn , Charles David Weaver , Colleen M. Niswender , Evan P. Lebois , Thomas M. Bridges
- 申请人： Craig W. Lindsley , Jeffrey P. Corn , Charles David Weaver , Colleen M. Niswender , Evan P. Lebois , Thomas M. Bridges
- 申请人地址： US TN Nashville
- 专利权人： VANDERBILT UNIVERSITY
- 当前专利权人： VANDERBILT UNIVERSITY
- 当前专利权人地址： US TN Nashville
- 国际申请： PCT/US2010/024802 WO 20100219
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; C07D409/14 ; A61P25/18 ; A61P25/16 ; A61P25/24 ; A61P25/00 ; A61P25/28 ; A61P25/14 ; C07D401/04 ; A61P25/22
摘要：
In one aspect, the invention relates to compounds having a general structure: Formula (I) which are useful as allosteric agonists of the M1 muscarinic receptor, synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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