A microdroplet generation apparatus comprises an oscillation plate having a first through-hole, a connection plate having a second through-hole corresponding to the first through-hole, a nozzle disc fixed to the connection plate and having a plurality of tiny injection holes on a region thereof corresponding to the first and second through-holes, and a bonding material joining together the oscillation plate and the connection plate. The connection plate has at least one side wall corresponding to and joined with a side wall of the contour or the first through-hole of the oscillation plate. The side walls of the connection plate increase the joined area of the connection plate, whereby is enhanced the joining strength of the connection plate and the oscillation plate, and whereby the connection plate can effectively conduct the vibration energy of the radial and longitudinal Rayleigh waves to the nozzle disc, and whereby is improved liquid atomization.