发明申请
US20120095040A1 CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
有权
环己基[C]吡咯-2-羧酸酯衍生物,其制备方法及其治疗用途
- 专利标题: CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
- 专利标题(中): 环己基[C]吡咯-2-羧酸酯衍生物,其制备方法及其治疗用途
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申请号: US13319908申请日: 2010-05-11
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公开(公告)号: US20120095040A1公开(公告)日: 2012-04-19
- 发明人: Ahmed Abouabdellah , Luc Even , Aude Fayol , Julien Vache , Philippe Yauche
- 申请人: Ahmed Abouabdellah , Luc Even , Aude Fayol , Julien Vache , Philippe Yauche
- 申请人地址: FR Paris
- 专利权人: SANOFI
- 当前专利权人: SANOFI
- 当前专利权人地址: FR Paris
- 优先权: FR09/02268 20090512
- 国际申请: PCT/FR10/50913 WO 20100511
- 主分类号: A61K31/4725
- IPC分类号: A61K31/4725 ; C07D413/12 ; C07D403/12 ; C07D413/14 ; C07D417/14 ; A61K31/427 ; A61K31/433 ; A61K31/422 ; A61K31/4196 ; A61K31/428 ; A61P29/00 ; A61P13/10 ; A61P13/00 ; A61P1/00 ; A61P11/00 ; A61P27/02 ; A61P19/10 ; A61P31/12 ; A61P31/04 ; A61P33/00 ; A61P37/08 ; A61P37/00 ; A61P35/00 ; A61P9/10 ; A61P9/00 ; A61P25/00 ; A61P25/08 ; A61P1/08 ; C07D417/12
摘要:
The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are a number from 0 to 3; A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a —O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group while the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group; R4 is an optionally substituted 5-membered heterocyclic compound; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.
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