Embodiments of the invention provide a method, system and computer program product for content caching with remote filtering services in a radio access network (RAN). In an embodiment of the invention, a method for content caching with remote filtering services in a RAN can include receiving a response to a request from an end user device wirelessly coupled to a base station of the RAN, marking the response as uncacheable, and routing the response to the base station over a data communications network. In one aspect of the embodiment, the response can be received in an RNC of the RAN. Of note, the process of marking the response as uncacheable can depend upon the evaluation of a policy with respect to the response. Finally, in another aspect of the embodiment, marking the response as uncacheable, can include annotating a hypertext transfer protocol (HTTP) header of the response to indicate that the response is not to be cached in the base station.