In accordance with aspects of the present invention, an applicator assembly suitable for application of a catheter patch with one hand comprises an upper arm with a proximal end and a distal portion, a lower arm with a proximal end and a distal portion, and a hinge member fixedly joining the proximal ends of the upper arm and the lower arm, wherein an upper surface of the upper arm distal portion abuts a lower surface of the lower arm distal portion. In accordance with another aspect of the present invention, a catheter patch assembly may be secured against a lower surface of the upper arm distal portion. The distal portion of the lower arm may include a securing mechanism for securing the catheter patch assembly to the applicator assembly. A method of applying a catheter patch is provided.