A system on chip (SoC) structure of a video codec-embedded image sensor and a method of driving an image sensor using the same are provided. The image sensor includes a first domain including a codec processing unit processing image data using a video codec and a core processor, a second domain including an image sensor pixel and an analog-to-digital converter (ADC), a third domain including an image signal processor (ISP) performing signal processing on the image data obtained from the second domain, a fourth domain including a formatter converting a data format of the data generated in the first to third domains to the outside, an a clock generation unit providing system clocks to the first to fourth domains, respectively.