A battery over-current protection controller includes a current sense circuit, a first pin coupled to one end of the current detection circuit, a second pin, and a third pin. The second pin and the third pin are respectively coupled to a positive end and a negative end of a battery module. The current sense circuit includes a reference voltage generation unit, a voltage dividing unit, and a comparison unit. The reference voltage generation unit is coupled between the second pin and the third pin to generate a reference voltage. The voltage dividing unit has one end coupled to the reference voltage to thereby generate a voltage dividing signal. The comparison unit receives the voltage dividing signal and a current detection signal indicative of a value of a current flowing through the current detection circuit to thereby generate an over-current protection signal when the current is greater than the predetermined current.