发明申请
- 专利标题： PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS
- 专利标题（中）： 吡咯羧酸衍生物作为抗菌剂
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申请号： US13056876申请日： 2009-07-30
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公开(公告)号： US20120108565A1公开(公告)日： 2012-05-03
- 发明人: Lalima Sharma , Jitendra A. Sattigeri , Narest Kumar , Ajay Yadav , Rijwan Momim , Shahadat Ahmed , Ian A. Cliffe , Pradip Kumar Bhatnagar , Sanjay Ghosh , V. Samuel Raj , Dilip J. Upadhyay
- 申请人： Lalima Sharma , Jitendra A. Sattigeri , Narest Kumar , Ajay Yadav , Rijwan Momim , Shahadat Ahmed , Ian A. Cliffe , Pradip Kumar Bhatnagar , Sanjay Ghosh , V. Samuel Raj , Dilip J. Upadhyay
- 优先权： IN1809/DEL/2008 20080730
- 国际申请： PCT/IB2009/053331 WO 20090730
- 主分类号： A61K31/403
- IPC分类号： A61K31/403 ; C07D401/14 ; C07D403/12 ; C07D413/14 ; A61K31/427 ; A61K31/4439 ; A61K31/428 ; A61K31/5377 ; A61K31/506 ; A61P31/04 ; A61P11/00 ; A61P17/00 ; A61P13/00 ; A61P19/08 ; C07D405/14 ; C07D407/14 ; C07D403/14 ; A61K31/422 ; A61K31/454 ; A61K31/496 ; C07D417/14
摘要：
The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Mvraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae (E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
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