发明申请
- 专利标题: AZABICYCLO COMPOUND AND SALT THEREOF
- 专利标题(中): 雅各布酯化合物及其盐
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申请号: US13378527申请日: 2010-07-09
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公开(公告)号: US20120108589A1公开(公告)日: 2012-05-03
- 发明人: Makoto Kitade , Shuichi Ohkubo , Chihoko Yoshimura , Satoshi Yamashita , Hiromi Oshiumi , Takao Uno , Yuichi Kawai
- 申请人: Makoto Kitade , Shuichi Ohkubo , Chihoko Yoshimura , Satoshi Yamashita , Hiromi Oshiumi , Takao Uno , Yuichi Kawai
- 申请人地址: JP Tokyo
- 专利权人: TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人: TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-164196 20090710
- 国际申请: PCT/JP10/04466 WO 20100709
- 主分类号: A61K31/437
- IPC分类号: A61K31/437 ; A61K31/5377 ; A61P35/00 ; C07D471/04
摘要:
It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.
公开/授权文献
- US08779142B2 Azabicyclo compound and salt thereof 公开/授权日:2014-07-15
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