发明申请
- 专利标题： TARGETING NUCLEIC ACIDS IN MITOCHONDRIA
- 专利标题（中）： 在三明治中瞄准核酸
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申请号： US13266431申请日： 2010-04-27
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公开(公告)号： US20120110693A1公开(公告)日： 2012-05-03
- 发明人: Laurence Drouard , Antonio Placido , Francois Sieber
- 申请人： Laurence Drouard , Antonio Placido , Francois Sieber
- 优先权： FR0952740 20090427
- 国际申请： PCT/FR2010/050792 WO 20100427
- 主分类号： A01H1/06
- IPC分类号： A01H1/06 ; C07K19/00 ; C12N15/62 ; C12N15/79 ; A01H5/10 ; C12N15/85 ; C12N15/81 ; C12N15/82 ; C12N15/80 ; A01H5/00 ; C12N1/00 ; A61K38/02
摘要：
The present invention relates to a shuttle system with which nucleic acids of interest may be imported into a mitochondrion. This system is based on the use of a fusion protein between a mitochondrial targeting sequence and a protein binding a nucleic acid of interest. This shuttle system is for example useful in agronomics, in the field of gene therapy, and within the scope of research products aiming at characterizing the function of mitochondrial genes.