A method and UE for setting a Happy bit on an uplink enhanced dedicated control channel are provided. The method includes: a UE transmits an uplink Enhanced Dedicated Channel (E-DCH) on more than one carrier, when criterion 1 and criterion 2 are met, the UE sets the Happy bit which is to be transmitted to a network side as “UNHAPPY” to indicate that the UE doesn't satisfy with the current serving grant. The disclosure optimizes the processing process of power control and resource scheduling, reduces call-drop rate, so that the performances of the UE and the NodeB are optimized.