Invention Application
US20120121501A1 HMGN2 PEPTIDES AND RELATED MOLECULES THAT SELECTIVELY HOME TO TUMOR BLOOD VESSELS AND TUMOR CELLS
有权
HMGN2肽和相关分子选择性地选择肿瘤血管和肿瘤细胞
- Patent Title: HMGN2 PEPTIDES AND RELATED MOLECULES THAT SELECTIVELY HOME TO TUMOR BLOOD VESSELS AND TUMOR CELLS
- Patent Title (中): HMGN2肽和相关分子选择性地选择肿瘤血管和肿瘤细胞
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Application No.: US13276237Application Date: 2011-10-18
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Publication No.: US20120121501A1Publication Date: 2012-05-17
- Inventor: Erkki Ruoslahti , Kimmo Porkka , Sven Christian
- Applicant: Erkki Ruoslahti , Kimmo Porkka , Sven Christian
- Applicant Address: US CA La Jolla
- Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
- Current Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
- Current Assignee Address: US CA La Jolla
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61K39/395 ; A61P35/00 ; C07K1/14 ; C07K16/18 ; C40B30/04 ; A61K47/48 ; A61K49/00
Abstract:
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided.
Public/Granted literature
- US08598112B2 HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells Public/Granted day:2013-12-03
Information query
