发明申请
US20120122909A9 SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
审中-公开
SPIRO-OXINDOLE化合物及其作为治疗剂的用途
- 专利标题: SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
- 专利标题(中): SPIRO-OXINDOLE化合物及其作为治疗剂的用途
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申请号: US13078678申请日: 2011-04-01
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公开(公告)号: US20120122909A9公开(公告)日: 2012-05-17
- 发明人: Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Ralna , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
- 申请人: Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Ralna , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
- 申请人地址: CA Burnaby
- 专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人地址: CA Burnaby
- 主分类号: A61K31/4747
- IPC分类号: A61K31/4747 ; A61K31/407 ; A61P25/24 ; A61P25/04 ; A61P9/00 ; A61P11/00 ; A61P25/18 ; A61P29/00 ; A61P25/06 ; A61P25/00 ; A61P43/00 ; A61P25/22 ; A61P9/10 ; A61P19/02 ; A61P35/00 ; A61P25/08 ; A61P9/06 ; C07D491/20
摘要:
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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