发明申请
- 专利标题： Modified Small Interfering RNA Molecules and Methods of Use
- 专利标题（中）： 改良的小干扰RNA分子和使用方法
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申请号： US13075944申请日： 2011-03-30
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公开(公告)号： US20120122962A1公开(公告)日： 2012-05-17
- 发明人: Jang HAN , Mi-Young SEO , Michael HOUGHTON
- 申请人： Jang HAN , Mi-Young SEO , Michael HOUGHTON
- 申请人地址： US CA Emeryville
- 专利权人： NOVARTIS VACCINES AND DIAGNOSTICS, INC.
- 当前专利权人： NOVARTIS VACCINES AND DIAGNOSTICS, INC.
- 当前专利权人地址： US CA Emeryville
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; A61P31/14 ; C12N1/21 ; C12N5/10 ; C12N1/19 ; C07H21/02 ; C12N15/63
摘要：
The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer.
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