发明申请
- 专利标题： Manufacturing process for tiotropium bromide
- 专利标题（中）： 噻托溴铵的制造工艺
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申请号： US13200975申请日： 2011-10-06
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公开(公告)号： US20120123125A1公开(公告)日： 2012-05-17
- 发明人: Milan SOUKUP
- 申请人： Milan SOUKUP
- 申请人地址： US TX Dallas
- 专利权人： Drug Process Licensing Associates, LLC
- 当前专利权人： Drug Process Licensing Associates, LLC
- 当前专利权人地址： US TX Dallas
- 主分类号： C07D491/08
- IPC分类号： C07D491/08 ; C07D409/14
摘要：
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).
公开/授权文献
- US08680297B2 Manufacturing process for tiotropium bromide 公开/授权日：2014-03-25
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