The present disclosure generally provides a stent-graft for insertion into a body vessel that comprises hydrophilic polyurethane hydrogel cuffs and an elongated cylindrical body. This stent-graft exhibits an enhanced ability to maintain its original position when placed into a patient and resist the potential of migration without causing excessive discomfort to the patient. Upon exposure to bodily fluids, the cuffs of the stent-graft expand to exert a sealing or anchoring force against the wall of the body vessel. Such a stent-graft overcomes many of the problems associated with conventional stent-grafts as currently used in many different applications, for example, endovascular repair and ureteral drainage.