发明申请
- 专利标题： METHODS OF TREATMENT USING SELECTIVE BCL-2 INHIBITORS
- 专利标题（中）： 使用选择性BCL-2抑制剂治疗的方法
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申请号： US13301898申请日： 2011-11-22
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公开(公告)号： US20120129853A1公开(公告)日： 2012-05-24
- 发明人: Steven Elmore , Andrew Souers , Li Chun Wang , Tariq Ghayur , Stuart J. Perper
- 申请人： Steven Elmore , Andrew Souers , Li Chun Wang , Tariq Ghayur , Stuart J. Perper
- 申请人地址： US IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： US IL Abbott Park
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61P37/06 ; A61P13/12 ; A61K31/496
摘要：
This invention pertains to methods of treating systemic lupus erythematosus, lupus nephritis or Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-xL.