Techniques are described herein that are capable of heterogeneously optimizing a file. Heterogeneous optimization involves optimizing regions of a file non-uniformly. For example, the regions of the file may be optimized to different extents. In accordance with this example, a different optimization technique may be used to optimize each region or subset of the regions. In one aspect, optimization designations are assigned to respective regions of a file based on access patterns that are associated with the respective regions. The file may be a database file, a virtualized storage file, or other suitable type of file. Each optimization designation indicates an extent to which the respective region is to be optimized. Each region may be optimized to the extent that is indicated by the respective optimization designation that is assigned to that region.