发明申请
US20120135408A1 UNC-45A SPLICE VARIANTS BASED CANCER DIAGNOSTICS AND THERAPEUTICS
有权
UNC-45A基于变量的癌症诊断和治疗
- 专利标题： UNC-45A SPLICE VARIANTS BASED CANCER DIAGNOSTICS AND THERAPEUTICS
- 专利标题（中）： UNC-45A基于变量的癌症诊断和治疗
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申请号： US13144476申请日： 2010-01-12
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公开(公告)号： US20120135408A1公开(公告)日： 2012-05-31
- 发明人: Henry Fredric Epstein , Wei Guo , Daisi Chen , Ram Singh
- 申请人： Henry Fredric Epstein , Wei Guo , Daisi Chen , Ram Singh
- 申请人地址： US TX Austin
- 专利权人： The Board of Regents of the University of Texas System
- 当前专利权人： The Board of Regents of the University of Texas System
- 当前专利权人地址： US TX Austin
- 国际申请： PCT/US10/20764 WO 20100112
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N5/09 ; G01N33/574 ; C07H21/02
摘要：
Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed.
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