发明申请
- 专利标题： AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS
- 专利标题（中）： 氨基四氢吡喃半乳聚糖PDE10抑制剂
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申请号： US13389270申请日： 2010-08-05
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公开(公告)号： US20120136012A1公开(公告)日： 2012-05-31
- 发明人: Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , John D. Schreier
- 申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , John D. Schreier
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp
- 当前专利权人： Merck Sharp & Dohme Corp
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US10/44482 WO 20100805
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D519/00 ; A61P25/18 ; A61P25/28 ; A61P25/14 ; C07D471/04 ; A61P25/22
摘要：
The present invention is directed to amino tetrahydro-pyridopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
公开/授权文献
- US08691827B2 Amino tetrahydro-pyridopyrimidine PDE10 inhibitors 公开/授权日：2014-04-08
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