发明申请
US20120142733A1 4-SUBSTITUTED-CYCLOHEXYLAMINO-4-PIPERIDINYL-ACETAMIDE ANTAGONISTS OF CCR2
有权
CCR2的4-取代的环己基氨基-4-哌啶基 - 乙酰胺拮抗剂
- 专利标题： 4-SUBSTITUTED-CYCLOHEXYLAMINO-4-PIPERIDINYL-ACETAMIDE ANTAGONISTS OF CCR2
- 专利标题（中）： CCR2的4-取代的环己基氨基-4-哌啶基 - 乙酰胺拮抗剂
-
申请号： US13307357申请日： 2011-11-30
-
公开(公告)号： US20120142733A1公开(公告)日： 2012-06-07
- 发明人: James C. Lanter , Thomas P. Markotan , Nalin Subasinghe , Zhihua Sui , Xuqing Zhang
- 申请人： James C. Lanter , Thomas P. Markotan , Nalin Subasinghe , Zhihua Sui , Xuqing Zhang
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; C07D405/14 ; C07D471/04 ; A61K31/4545 ; A61P11/00 ; A61P27/02 ; A61P29/00 ; A61P17/06 ; A61P19/02 ; A61P17/00 ; A61P25/00 ; A61P1/00 ; A61P1/04 ; A61P13/12 ; A61P37/06 ; A61P3/10 ; A61P3/04 ; A61P5/48 ; A61P3/00 ; A61P31/06 ; A61P37/08 ; A61P27/14 ; A61P11/06 ; A61P1/02 ; A61P9/00 ; A61P9/10 ; A61P9/04 ; A61P35/00 ; A61P35/02 ; C07D401/12
摘要：
The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, X, Y, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
公开/授权文献
信息查询
IPC分类:
