发明申请
- 专利标题： MODULATION OF TIMP1 AND TIMP2 EXPRESSION
- 专利标题（中）： TIMP1和TIMP2表达的调控
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申请号： US13246621申请日： 2011-09-27
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公开(公告)号： US20120142754A1公开(公告)日： 2012-06-07
- 发明人: Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
- 申请人： Yoshiro Niitsu , Hirokazu Takahashi , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett
- 专利权人： Quark Pharmaceuticals, Inc.,Nitto Denko Technical Corporation
- 当前专利权人： Quark Pharmaceuticals, Inc.,Nitto Denko Technical Corporation
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61P43/00 ; C07H21/02
摘要：
Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
公开/授权文献
- US20130030034A9 MODULATION OF TIMP1 AND TIMP2 EXPRESSION 公开/授权日：2013-01-31