发明申请
- 专利标题： NOVEL UBIQUITIN LIGASE AND USE THEREOF
- 专利标题（中）： 新型UBIQUITIN LIGASE及其用途
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申请号： US13389065申请日： 2010-08-06
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公开(公告)号： US20120145544A1公开(公告)日： 2012-06-14
- 发明人: Kazuhiro Iwai
- 申请人： Kazuhiro Iwai
- 优先权： JP2009-184878 20090807
- 国际申请： PCT/JP2010/063345 WO 20100806
- 主分类号： C12N9/00
- IPC分类号： C12N9/00 ; C12N5/10 ; C07K1/26 ; C12N15/63 ; G01N33/559 ; C12N1/19 ; C12N1/21
摘要：
Provided is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified. It was found out that a complex of (a) a protein having a part of HOIP and at least having a UBA region and a RING-IBR-RING region thereof, and (b) One or more kinds of proteins which individually form a complex with the above (a) is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified.
公开/授权文献
- US08546094B2 Ubiquitin ligase and use thereof 公开/授权日：2013-10-01