发明申请
US20120149683A1 SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES
有权
替代的氨基磷酸酯作为用于治疗糖尿病的DIPEPTIDYL PEPTIDASE-IV抑制剂
- 专利标题： SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES
- 专利标题（中）： 替代的氨基磷酸酯作为用于治疗糖尿病的DIPEPTIDYL PEPTIDASE-IV抑制剂
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申请号： US13390708申请日： 2010-09-15
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公开(公告)号： US20120149683A1公开(公告)日： 2012-06-14
- 发明人: Jason M. Cox , Tesfaye Biftu , Hong Dong Chu , Danqing Feng , Ann E. Weber
- 申请人： Jason M. Cox , Tesfaye Biftu , Hong Dong Chu , Danqing Feng , Ann E. Weber
- 国际申请： PCT/US10/48871 WO 20100915
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; C07D401/12 ; A61K31/497 ; C07D401/06 ; A61P3/10 ; C07D487/04 ; A61K31/4985 ; C07D413/06 ; A61K31/5377 ; C07D211/56 ; A61K31/4545
摘要：
The present invention is directed to novel substituted aminopiperidines of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-ÏV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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