Systems, devices and methods of use adapted for treatment of respiratory disease or sleep disordered breathing include a patient interface (10) adapted to be secured to and sealed against a portion of a patient's face, in use. A flow generator is adapted to be connected to the patient interface and to be secured by a portion of the patient's body. The flow generator includes a blower (50) adapted to provide pressurised breathable gas to a patient through the patient interface. The blower is adapted to be at least partially vibrationally isolated from the patient's body by at least one dampening system (49) or device. The dampening device or system is adapted to reduce the amount of transmitted vibration received by the patient. A PAP system includes a patient interface including sealing arrangement (30) adapted to form a seal with the patient's nose and/or mouth and headgear (40) to support the sealing arrangement in position on the patient's head. A blower is structured to generate a supply of pressurized air. The blower is supported by the patient interface on the patient's head and in communication with the patient interface. The headgear forms one or more ducts (42) to communicate pressurized air from the blower to a breathing cavity defined by the sealing arrangement.