发明申请
US20120157371A1 HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS
有权
抗微生物和抗微生物相关化合物的高渗透性原料组合物
- 专利标题: HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS
- 专利标题(中): 抗微生物和抗微生物相关化合物的高渗透性原料组合物
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申请号: US13323556申请日: 2011-12-12
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公开(公告)号: US20120157371A1公开(公告)日: 2012-06-21
- 发明人: Chongxi YU , Lina Xu , Yuhua Chen , Binbing Yan , Shiqian Tu
- 申请人: Chongxi YU , Lina Xu , Yuhua Chen , Binbing Yan , Shiqian Tu
- 优先权: CN200910141944.X 20090610
- 主分类号: A61K38/12
- IPC分类号: A61K38/12 ; A61K31/431 ; C07D499/46 ; A61K31/43 ; C07D499/64 ; C07D499/68 ; C07D499/70 ; C07D501/60 ; A61K31/546 ; A61K31/545 ; A61K31/675 ; C07F9/6561 ; C07F9/40 ; C07F9/6506 ; C12Q1/02 ; C07K7/64 ; A61P31/00 ; A61P31/04 ; A61P31/16 ; A61P31/10 ; A61P31/12 ; A61P1/16 ; A61P11/00 ; A61P1/00 ; A61P25/00 ; A61P13/12 ; A61P9/00 ; A61P27/02 ; A61P17/00 ; A61P1/18 ; C07D499/76
摘要:
The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.