Invention Application
- Patent Title: RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
- Patent Title (中): RAF抑制剂化合物及其使用方法
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Application No.: US13393163Application Date: 2010-08-27
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Publication No.: US20120157439A1Publication Date: 2012-06-21
- Inventor: Ignacio Aliagas , Stefan Gradl , Janet Gunzner , Simon Mathieu , Rebecca Pulk , Joachim Rudolph , Zhaoyang Wen , Jonas Grina , Joshua D. Hansen , Ellen Laird , David Moreno , Li Ren , Steven Mark Wenglowsky
- Applicant: Ignacio Aliagas , Stefan Gradl , Janet Gunzner , Simon Mathieu , Rebecca Pulk , Joachim Rudolph , Zhaoyang Wen , Jonas Grina , Joshua D. Hansen , Ellen Laird , David Moreno , Li Ren , Steven Mark Wenglowsky
- Applicant Address: US CA South San Francisco US CO Boulder
- Assignee: GENENTECH, INC.,ARRAY BIOPHARMA INC.
- Current Assignee: GENENTECH, INC.,ARRAY BIOPHARMA INC.
- Current Assignee Address: US CA South San Francisco US CO Boulder
- International Application: PCT/US10/46955 WO 20100827
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D495/04 ; A61P35/00 ; A61K31/5377 ; A61K31/53 ; C07D487/04 ; C07D513/04
Abstract:
Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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