发明申请
- 专利标题： RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
- 专利标题（中）： RAF抑制剂化合物及其使用方法
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申请号： US13393163申请日： 2010-08-27
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公开(公告)号： US20120157439A1公开(公告)日： 2012-06-21
- 发明人: Ignacio Aliagas , Stefan Gradl , Janet Gunzner , Simon Mathieu , Rebecca Pulk , Joachim Rudolph , Zhaoyang Wen , Jonas Grina , Joshua D. Hansen , Ellen Laird , David Moreno , Li Ren , Steven Mark Wenglowsky
- 申请人： Ignacio Aliagas , Stefan Gradl , Janet Gunzner , Simon Mathieu , Rebecca Pulk , Joachim Rudolph , Zhaoyang Wen , Jonas Grina , Joshua D. Hansen , Ellen Laird , David Moreno , Li Ren , Steven Mark Wenglowsky
- 申请人地址： US CA South San Francisco US CO Boulder
- 专利权人： GENENTECH, INC.,ARRAY BIOPHARMA INC.
- 当前专利权人： GENENTECH, INC.,ARRAY BIOPHARMA INC.
- 当前专利权人地址： US CA South San Francisco US CO Boulder
- 国际申请： PCT/US10/46955 WO 20100827
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D495/04 ; A61P35/00 ; A61K31/5377 ; A61K31/53 ; C07D487/04 ; C07D513/04
摘要：
Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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