发明申请
US20120157537A1 NMDA receptor antagonists and their use in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau
审中-公开
NMDA受体拮抗剂及其用于抑制微管相关蛋白tau异常高磷酸化的用途
- 专利标题： NMDA receptor antagonists and their use in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau
- 专利标题（中）： NMDA受体拮抗剂及其用于抑制微管相关蛋白tau异常高磷酸化的用途
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申请号： US13134615申请日： 2011-06-10
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公开(公告)号： US20120157537A1公开(公告)日： 2012-06-21
- 发明人: Khalid Iqbal , Inge Grundke-Iqbal
- 申请人： Khalid Iqbal , Inge Grundke-Iqbal
- 主分类号： A61K31/13
- IPC分类号： A61K31/13 ; A61P25/16 ; A61P25/00 ; A61P25/08 ; A61P27/06 ; A61P31/14 ; A61P25/14 ; A61P25/36 ; A61P25/32 ; A61P25/30 ; A61P25/04 ; A61P33/06 ; A61P25/28 ; A61P1/16
摘要：
Aminocyclohexane and aminoalkylcyclohexane compounds, which are systemically-active as NMDA receptor antagonists, are effective in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau, method of treating disorders resulting from or associated with abnormal hyperphosphorylation of microtubule associated protein tau, and pharmaceutical compositions comprising the same.
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