The present disclosure relates to a process for the conversion of oxygen-containing hydrocarbons into long-chain hydrocarbons suitable for use as a fuel. These hydrocarbons may be derived from biomass, and may optionally be mixed with petroleum-derived hydrocarbons prior to conversion. The process utilizes a catalyst comprising Ni and Mo to convert a mixture comprising oxygenated hydrocarbons into product hydrocarbons containing from ten to thirty carbons. Hydro-conversion can be performed at a significantly lower temperature than is required for when utilizing a hydrotreating catalyst comprising Co and Mo (CoMo), while still effectively removing sulfur compounds (via hydrodesulfurization) to a level of 10 ppm (by weight) or less.