Invention Application
US20120165326A1 DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO BENZOTHIAZOLES AND 5-FLUORO BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
审中-公开
6-(6-取代的三唑并吡嗪 - 磺酰)5-氟代苯并咪唑的衍生物及其制备方法及其作为药物的用途及其作为抑制剂的用途
- Patent Title: DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO BENZOTHIAZOLES AND 5-FLUORO BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
- Patent Title (中): 6-(6-取代的三唑并吡嗪 - 磺酰)5-氟代苯并咪唑的衍生物及其制备方法及其作为药物的用途及其作为抑制剂的用途
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Application No.: US13147644Application Date: 2010-02-04
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Publication No.: US20120165326A1Publication Date: 2012-06-28
- Inventor: Conception Nemecek , Antonio Ugolini , Eric Bacque , Dominique Damour , Gilles Barbalat , Sylvie Wentzler
- Applicant: Conception Nemecek , Antonio Ugolini , Eric Bacque , Dominique Damour , Gilles Barbalat , Sylvie Wentzler
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Priority: FR0900514 20090206
- International Application: PCT/FR10/50180 WO 20100204
- Main IPC: A61K31/5025
- IPC: A61K31/5025 ; A61K31/5377 ; C07D277/82 ; A61P35/00 ; A61P9/00 ; A61P3/00 ; A61P37/08 ; A61P11/06 ; A61P7/02 ; A61P25/00 ; A61P9/10 ; A61P3/10 ; A61P21/00 ; A61P17/06 ; A61P19/02 ; A61P35/04 ; C07D417/12 ; A61P29/00 ; C07D487/04

Abstract:
The invention relates to novel products of the formula (I) where: (II) is a single or double bond; F is a fluorine atom, Ra is H, HaI, alkoxy, O-cycloalkyl, —O— heterocycloalkyl; —NH-heterocycloalkyl, heteroaryl, phenyl, NHCOalk NHCOcycloalk or NR1 R2; X is S, SO or SO2, A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl optionally substituted by NR3R4, alkoxy, hydroxy, phenyl, heteroaryl or heterocycloalkyl; alkoxy optionally substituted by NR3R4, i.e. a O—(CH2)n-NR3R4 radical, an O-phenyl or an O—(CH2)n-phenyl radical, with phenyl optionally substituted and n=1 to 4; or the NR1 R2 radical; R1 is H or alk and R2 is H, cycloalkyl or alkyl; R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl; R1, R2 and/or R3, R4 form a cycle together with N optionally containing O, S, N and/or NH; heterocycloalkyl, heteroaryl and phenyl and cycles all being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
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