发明申请
- 专利标题： Compounds and their use as BACE inhibitors
- 专利标题（中）： 化合物及其作为BACE抑制剂的用途
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申请号： US13331231申请日： 2011-12-20
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公开(公告)号： US20120165346A1公开(公告)日： 2012-06-28
- 发明人: Karin Kolmodin , Britt-Marie Swahn , Jacob Kihlström , Johan Lindström , Sofia Karlström , Marie Sundström , Stefan Von Berg
- 申请人： Karin Kolmodin , Britt-Marie Swahn , Jacob Kihlström , Johan Lindström , Sofia Karlström , Marie Sundström , Stefan Von Berg
- 申请人地址： SE Sodertalje
- 专利权人： ASTRAZENECA AB
- 当前专利权人： ASTRAZENECA AB
- 当前专利权人地址： SE Sodertalje
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61P25/28 ; A61P25/00 ; C07D401/14 ; A61K31/444
摘要：
The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
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