Invention Application
- Patent Title: NOVEL TUBULIN INHIBITORS AND METHODS OF USING THE SAME
- Patent Title (中): 新型维生素抑制剂及其使用方法
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Application No.: US13340103Application Date: 2011-12-29
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Publication No.: US20120172374A1Publication Date: 2012-07-05
- Inventor: Meng-Hsin Chen , Shih-Hsien Chuang , Yi-Jen Chen , Lien-Hsiang Chang , Tsung-Hui Li , Ching-Hui Chen , Win-Yin Wei
- Applicant: Meng-Hsin Chen , Shih-Hsien Chuang , Yi-Jen Chen , Lien-Hsiang Chang , Tsung-Hui Li , Ching-Hui Chen , Win-Yin Wei
- Applicant Address: TW New Taipei City
- Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- Current Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- Current Assignee Address: TW New Taipei City
- Main IPC: A61K31/426
- IPC: A61K31/426 ; C07D417/12 ; A61K31/4439 ; A61P7/00 ; A61K31/496 ; C07D405/12 ; A61P35/00 ; C07D277/42 ; C07D417/04
Abstract:
Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: R2—Y—Z-Q-A-R1 Formula (I) wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.
Public/Granted literature
- US08883793B2 Tubulin inhibitors and methods of using the same Public/Granted day:2014-11-11
Information query
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