发明申请
- 专利标题： NOVEL TUBULIN INHIBITORS AND METHODS OF USING THE SAME
- 专利标题（中）： 新型维生素抑制剂及其使用方法
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申请号： US13340103申请日： 2011-12-29
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公开(公告)号： US20120172374A1公开(公告)日： 2012-07-05
- 发明人: Meng-Hsin Chen , Shih-Hsien Chuang , Yi-Jen Chen , Lien-Hsiang Chang , Tsung-Hui Li , Ching-Hui Chen , Win-Yin Wei
- 申请人： Meng-Hsin Chen , Shih-Hsien Chuang , Yi-Jen Chen , Lien-Hsiang Chang , Tsung-Hui Li , Ching-Hui Chen , Win-Yin Wei
- 申请人地址： TW New Taipei City
- 专利权人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- 当前专利权人： DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- 当前专利权人地址： TW New Taipei City
- 主分类号： A61K31/426
- IPC分类号： A61K31/426 ; C07D417/12 ; A61K31/4439 ; A61P7/00 ; A61K31/496 ; C07D405/12 ; A61P35/00 ; C07D277/42 ; C07D417/04
摘要：
Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: R2—Y—Z-Q-A-R1 Formula (I) wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.
公开/授权文献
- US08883793B2 Tubulin inhibitors and methods of using the same 公开/授权日：2014-11-11
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