发明申请
US20120178906A1 CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES
审中-公开
通过磷酸盐还原含有崩解剂的化合物将金属螯合到硫醇组合
- 专利标题： CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES
- 专利标题（中）： 通过磷酸盐还原含有崩解剂的化合物将金属螯合到硫醇组合
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申请号： US13423751申请日： 2012-03-19
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公开(公告)号： US20120178906A1公开(公告)日： 2012-07-12
- 发明人: Aldo Cagnolini , Karen E. Linder , Kondareddiar Ramalingam , Hong (Helen) Fan
- 申请人： Aldo Cagnolini , Karen E. Linder , Kondareddiar Ramalingam , Hong (Helen) Fan
- 申请人地址： IT Milan
- 专利权人： BRACCO IMAGING S.P.A.
- 当前专利权人： BRACCO IMAGING S.P.A.
- 当前专利权人地址： IT Milan
- 主分类号： C07K2/00
- IPC分类号： C07K2/00
摘要：
A method is disclosed for the syntheses of thiol-containing radiopharmaceuticals without the need for purification starting from chelators containing disulfide bonds. This is done by providing a method that reduces disulfide bonds on a precursor molecule or a precursor compound in the presence of phosphine compounds, thus freeing thiols for metal complexation.