Embodiments of the invention are generally directed to conversion and processing of deep color video in a single clock domain. An embodiment of a method includes receiving one or more video data streams, the one or more video data streams including a first video data stream, the first video data stream being clocked at a frequency of a link clock signal. The method further includes converting the first video data stream into a converted video data stream having a modified data format, wherein the modified data format includes transfer of a single pixel of data in one cycle of the link clock signal and the insertion of null data to fill empty cycles of the converted video data stream, and generation of a valid data signal to distinguish between valid video data and the null data in the converted video data stream. The method further includes processing the converted video data stream according to the frequency of the link clock signal to generate a processed data stream from the converted video data stream, wherein processing includes using the valid data signal to identify valid video data.