发明申请
- 专利标题: MODULATORS FOR AMYLOID BETA
- 专利标题(中): AMYLOID BETA的调节剂
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申请号: US13437057申请日: 2012-04-02
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公开(公告)号: US20120190682A1公开(公告)日: 2012-07-26
- 发明人: Erwin Goetschi , Synese Jolidon , Thomas Luebbers
- 申请人: Erwin Goetschi , Synese Jolidon , Thomas Luebbers
- 优先权: EP08166228.0 20081009
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; A61K31/53 ; C07D401/14 ; A61P7/04 ; C07D403/14 ; A61P25/28 ; A61P25/00 ; C07D403/12 ; C07D413/14
摘要:
The invention relates to compounds of formula wherein R1, R2, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compounds of formula I are modulators for amyloid beta and may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
公开/授权文献
- US08389717B2 Modulators for amyloid beta 公开/授权日:2013-03-05
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