An up-cutting knife that has particular application for minimally invasive spinal surgical procedures. The knife includes an elongated tube that is operable to be inserted through a tubular retractor used in minimally invasive surgical procedures. One end of the elongated tube includes a curved head portion having a cutting blade formed on a top surface thereof and a suction port, and an opposite end of the tube is coupled to a handle having a chamber. A suction device can be coupled to an outlet port in the handle that causes blood and other surgical material to be drawn through the tube and out of the handle.