发明申请
US20120202802A1 SPIROCYCLIC COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
有权
作为化合物受体活性调节剂的螺旋化合物
- 专利标题： SPIROCYCLIC COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
- 专利标题（中）： 作为化合物受体活性调节剂的螺旋化合物
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申请号： US13500323申请日： 2010-10-06
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公开(公告)号： US20120202802A1公开(公告)日： 2012-08-09
- 发明人: T.G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
- 申请人： T.G. Murali Dhar , John V. Duncia , Daniel S. Gardner , Weiwei Guo , John Hynes
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 国际申请： PCT/US2010/051577 WO 20101006
- 主分类号： A61K31/537
- IPC分类号： A61K31/537 ; C07D401/12 ; A61K31/527 ; A61K31/454 ; C07D471/10 ; A61K31/4545 ; A61K31/4523 ; A61P1/00 ; A61P19/02 ; A61P25/00 ; A61P29/00 ; A61P9/00 ; A61P31/18 ; A61P17/06 ; A61P11/00 ; A61P13/12 ; A61P11/06 ; A61P9/10 ; A61P35/00 ; C07D405/12 ; C07D413/12
摘要：
The present application describes modulators of chemokine receptor activity of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
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