发明申请
- 专利标题: FUSED AMINODIHYDRO-OXAZINE DERIVATIVES
- 专利标题(中): 熔融氨基二氧杂环丁烷衍生物
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申请号: US13386092申请日: 2010-07-21
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公开(公告)号: US20120202804A1公开(公告)日: 2012-08-09
- 发明人: John Mark Ellard , Christopher Neil Farthing , Adrian Hall
- 申请人: John Mark Ellard , Christopher Neil Farthing , Adrian Hall
- 申请人地址: JP Tokyo
- 专利权人: EISAI R&D MANAGEMENT CO., LTD.
- 当前专利权人: EISAI R&D MANAGEMENT CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: GB0912778.8 20090722
- 国际申请: PCT/EP2010/060587 WO 20100721
- 主分类号: A61K31/5365
- IPC分类号: A61K31/5365 ; A61P25/28 ; C07D498/04
摘要:
A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
公开/授权文献
- US09079914B2 Fused aminodihydro-oxazine derivatives 公开/授权日:2015-07-14
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