发明申请
- 专利标题: PYRIMIDONE DERIVATIVES
- 专利标题(中): 吡咯烷酮衍生物
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申请号: US13389512申请日: 2010-08-11
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公开(公告)号: US20120208797A1公开(公告)日: 2012-08-16
- 发明人: Kazuki Nakayama , Daiki Sakai , Kazutoshi Watanabe , Toshiyuki Kohara , Keiichi Aritomo
- 申请人: Kazuki Nakayama , Daiki Sakai , Kazutoshi Watanabe , Toshiyuki Kohara , Keiichi Aritomo
- 申请人地址: FR Paris JP Osaka
- 专利权人: SANOFI,MITSUBISHI TANABE PHARMA CORPORATION
- 当前专利权人: SANOFI,MITSUBISHI TANABE PHARMA CORPORATION
- 当前专利权人地址: FR Paris JP Osaka
- 优先权: JP2009-204096 20090813
- 国际申请: PCT/JP2010/063891 WO 20100811
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61K31/506 ; C07D413/14 ; A61K31/5377 ; C07D265/14 ; A61K31/536 ; A61P25/28 ; A61P25/00 ; A61P25/16 ; A61P3/10 ; A61P3/04 ; A61P25/24 ; A61P25/18 ; A61P35/00 ; A61P35/02 ; A61P33/06 ; C07D403/14
摘要:
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom or a C1-C3 alkyl group; L represents single bond or a C1-C6 alkylene group which may be substituted; Y represents single bond, sulfur atom, oxygen atom, NH, or the like; R2 represents hydrogen atom or a cyclic group which may be substituted, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
公开/授权文献
- US09006232B2 Pyrimidone derivatives 公开/授权日:2015-04-14