发明申请
- 专利标题: ROS Kinase in Lung Cancer
- 专利标题(中): ROS激酶在肺癌
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申请号: US13113676申请日: 2011-05-23
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公开(公告)号: US20120208824A1公开(公告)日: 2012-08-16
- 发明人: Victoria McGuinness Rimkunas , Herbert Haack , Ting-Lei Gu , Ailan Guo , Anthony Paul Possemato , Katherine Eleanor Crosby , Meghan Ann Tucker , Cynthia Reeves
- 申请人: Victoria McGuinness Rimkunas , Herbert Haack , Ting-Lei Gu , Ailan Guo , Anthony Paul Possemato , Katherine Eleanor Crosby , Meghan Ann Tucker , Cynthia Reeves
- 申请人地址: US MA Danvers
- 专利权人: Cell Signaling Technology, Inc.
- 当前专利权人: Cell Signaling Technology, Inc.
- 当前专利权人地址: US MA Danvers
- 主分类号: A61K31/4545
- IPC分类号: A61K31/4545 ; A61K31/506 ; G01N33/574 ; G01N33/53 ; C12Q1/68 ; A61P35/00 ; G01N33/573
摘要:
The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., an lung cancer).