发明申请
US20120208986A1 USE OF MIXED MODE CHROMATOGRAPHY FOR THE CAPTURE AND PURIFICATION OF BASIC ANTIBODY PRODUCTS
审中-公开
混合模式色谱法用于检测和纯化基础抗体产品
- 专利标题： USE OF MIXED MODE CHROMATOGRAPHY FOR THE CAPTURE AND PURIFICATION OF BASIC ANTIBODY PRODUCTS
- 专利标题（中）： 混合模式色谱法用于检测和纯化基础抗体产品
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申请号： US13502930申请日： 2010-10-13
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公开(公告)号： US20120208986A1公开(公告)日： 2012-08-16
- 发明人: Marc D. Wenger , Matthew Woodling
- 申请人： Marc D. Wenger , Matthew Woodling
- 国际申请： PCT/US10/52459 WO 20101013
- 主分类号： C07K1/16
- IPC分类号： C07K1/16 ; C07K16/12
摘要：
Use of mixed mode chromatography for purification of an antibody from an antibody mixture, for example) a Pichia pastoris fermentation mixture containing impurities such as host cell proteins and DNA is described Mixed mode chromatography is used instead of protein A chromatography and presents certain advantages over protein A chromatography Furthermore, the integration of such a method into a multi-step procedure with other fractionation methods for purification of antibodies suitable for in vivo applications is provided.
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