A safety gate has a frame with spaced apart top and bottom assemblies and spaced apart side assemblies in a deployed configuration. The top and bottom assembly length is extendable and retractable between the opposed side assemblies. A flexible barrier is connected to the frame. A one-way jack mechanism can be carried on each of the top and bottom assemblies. The length of the assemblies can be extended without actuating the jack mechanisms to adjust the frame to nearly fit a space between two surfaces. The jack mechanisms, when actuated, incrementally further extend the top and bottom assemblies so the frame interferingly fits between the two surfaces under compression. The frame can be reconfigurable between a compact configuration and the deployed configuration. The side assemblies can include latches that lock the frame in the deployed configuration.