A fuel cell is disclosed comprising: a power generation layer including an electrolyte membrane, and an anode and a cathode provided on respective surfaces of the electrolyte membrane; a fuel gas flow path layer located on a side of the anode of the power generation layer to supply a fuel gas to the anode while flowing the fuel gas along a flow direction of the fuel gas approximately orthogonal to a stacking direction in which respective layers of the fuel cell are stacked; and an oxidizing gas flow path layer located on a side of the cathode of the power generation layer to supply an oxidizing gas to the cathode while flowing the oxidizing gas along a flow direction of the oxidizing gas opposed to the flow direction of the fuel gas. A power generation area of the fuel cell, in which electric power is generated, has an upstream region including a most upstream position along the flow direction of the fuel gas and a downstream region including a most downstream position along the flow direction of the fuel gas. A midstream region, which is a remaining region of the power generation area other than the upstream region and the downstream region, has higher water vapor transfer resistance between the anode side and the cathode side than the upstream region and the downstream region.