发明申请
US20120214240A1 VECTORS FOR GENERATING PLURIPOTENT STEM CELLS AND METHODS OF PRODUCING PLURIPOTENT STEM CELLS USING THE SAME
有权
用于产生多发性干细胞的方法和使用该方法生产细胞干细胞的方法
- 专利标题： VECTORS FOR GENERATING PLURIPOTENT STEM CELLS AND METHODS OF PRODUCING PLURIPOTENT STEM CELLS USING THE SAME
- 专利标题（中）： 用于产生多发性干细胞的方法和使用该方法生产细胞干细胞的方法
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申请号： US13292953申请日： 2011-11-09
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公开(公告)号： US20120214240A1公开(公告)日： 2012-08-23
- 发明人: Mahito NAKANISHI , Ken NISHIMURA , Masayuki SANO , Manami OHTAKA
- 申请人： Mahito NAKANISHI , Ken NISHIMURA , Masayuki SANO , Manami OHTAKA
- 申请人地址： JP Tokyo
- 专利权人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- 当前专利权人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
- 当前专利权人地址： JP Tokyo
- 优先权： JPPCT/JP2010/058368 20100518; JP2010-250993 20101109
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N5/0789 ; C07H21/02 ; C12N7/01
摘要：
A reprogramming gene-loaded Sendai viral vector comprising Sendai virus genes and reprogramming genes, wherein the Sendai virus genes include an NP gene, P/C gene, M gene, F gene, HN gene and L gene, wherein each of the M gene, the F gene and the FIN gene is from a Sendai virus strain Cl.151-derived gene and wherein at least one of the M gene, the F gene and the HN gene is functionally deleted and the L gene encodes the amino-acid sequence of the L protein in which the amino-acid residue at position 1618 is valine and a method of producing the same.
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