发明申请
- 专利标题： SPECIFIC SALT, ANHYDROUS AND CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE
- 专利标题（中）： 二盐酸盐衍生物的特殊盐，无机和结晶形式
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申请号： US13457991申请日： 2012-04-27
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公开(公告)号： US20120214995A1公开(公告)日： 2012-08-23
- 发明人: Guenter Linz , Peter Sieger , Matthias Grauert , Rolf Schmid
- 申请人： Guenter Linz , Peter Sieger , Matthias Grauert , Rolf Schmid
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP06101414 20060208
- 主分类号： C07D475/06
- IPC分类号： C07D475/06
摘要：
The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.